China 200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH Manufacture and Factory |Jiayinglai

200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH

Tsanangudzo Pfupi

Chitarisiko	Machena kusvika kuOff-White makristasi kana crystalline poda.
MF	C24H38N4O7S
MW	526.65
Kuchena	98+

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Product Detail

Mamiriro ekufambisa & inokurudzirwa nzira yekutumira:
nemhepo, negungwa kana nekutaura

Mamiriro ekuchengetera:
Yakavharwa pakaoma,Chengeta mufiriji, pasi pe -20°C

Minimum Order Qty:
Kukurukurirana

Certification:
COA, HPLC, GC, HNMR, Assay, Mvura Yemukati(KF), TLC iripo

Mashoko anoreva zvakafanana

N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl)sulfonyl]amino]iminomethyl]-N2-BOC-L-ornithine;
Nα-Boc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl) -L-arginine;
Nalpha-Boc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-sulfonyl)-L-arginine;
BOC-ARGININE(PBF)-OH;BOC-L-ARG(PBF)-OH;
BOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE

Inner Packing

Vanowanzo shandiswa kutakura hupfu.Uye vanogona kudzivirira kupenya kwezuva nemvura kuti zvisashata.

kurongedza kwekunze

Iyo hard carton inogona kuchengetedza zvigadzirwa zvako kubva pakuputsika uye kunyorova.

Applications

Boc-Arg (Pbf) -OH inotorwa nearginine.
Bivalirudine, a synthetic anticoagulant ari 20-peptide cousin yehirudin, yakabvumirwa kutengeswa muUnited States muna 2000. Jekiseni chinhu chichena, chakasununguka kana kuti amorphous solid.Bivarudine inogona kusunga zvakananga kune thrombin catalytic site uye anion kunze kwekusungirirwa nzvimbo, uye inodzivisa zvakananga basa re thrombin, nokudaro kudzivisa maitiro anokonzerwa uye anokonzerwa ne thrombin, uye mhedzisiro yayo inodzorerwa.Bivarudine inonyanya kushandiswa se anticoagulant ye elective percutaneous coronary intervention (PCI) muvakuru.
Bivarudine inhibitor yakananga ye thrombin, iyo inonyanya kusungira kunzvimbo dzinokonzera uye anion exo-binding nzvimbo dzethrombin dzakasununguka uye pane thrombus.Kusunga muitiro pakati pebivaludine nethrombin kunodzoserwa shure, uye thrombin inogona kudzorera chepakutanga biological chiitiko chethrombin zvishoma nezvishoma enzymolysis ye peptide bond pakati bivaludine Arg3-Pro4.
In vitro zvidzidzo zvakaratidza kuti bivarudine haigoni kungodzivisa lateral yakasununguka thrombin, asiwo inhibisa thrombin inosunga nekuvhara ropa pasina kuderedzwa nezvinhu zvinobudiswa nemaplatelet.Inogona kurebesa chikamu cheprothrombin nguva (APTT), thrombin nguva (TT), prothrombin nguva (PT) uye inoshanda coagulation nguva (ACT) inoshandiswa neyakajairwa plasma.Pane hukama hwemutsara nehuwandu hwebivarudine, asi kana kuwirirana uku kuripo mukushandiswa kwekliniki hazvina kujeka.
Izvo zvakataurwa mumabhuku kuti pharmacokinetics yevarwere vari pasi pepercutaneous coronary angioplasty (PTCA) ine mutsara mushure mokunge intravenous administration ye bivarudine.Murwere akapiwa 1 mg / kg intravenously semutoro wemutoro, uchiteverwa neimwe IV infusion ye 2.5 mg / kg / hr kwemaawa 4, iyo yakagadzikana pa 12.3 ± 1.7 mg / ml mu vivo.Bivarudine inocheneswa kubva muplasma nerenal hydrolysis uye protease degradation.The clearance hafu yeupenyu hwevarwere vane yakajairika renal basa anenge 25min, uye clearance hafu yeupenyu hwevarwere vane mwero uye yakaoma renal insufficiency inowedzerwa.Inenge 25% yebivarudine inogona kubviswa ne dialysis uye kucheneswa nehemodialysis.ACT inofanirwa kuongororwa kune varwere vane renal impairment.Mune vanozvipira vane hutano, iyo anticoagulant effect yakakurumidza kuonekwa mushure me intravenous administration ye bivarudine, ine PT yakareba, ACT uye APTT.Iawa imwe kusvika maviri mushure mekubviswa, ACT yakadzokera kune pre-administration level.

zvinoenderana zvigadzirwa

Cbz-Phe-Arg-OH	Boc-L-Arg-OH.HCl
Arg-Tyr-Oet	Boc-L-Arg-OH.HCl.H2O
HL-Arg-OH	Boc-D-Arg-OH•HCl•H2O
HD-Arg-OH	Boc-Arg(Cbz)-OH
DL-Arg-OH	Fmoc-L-Arg-OH
L-Arg-Ome.2Hcl	Fmoc-D-Arg-OH
D-Arg-Ome.2HCl	Fmoc-L-Arg(NO2)-OH
L-Arg(Pbf)-OH	Fmoc-L-Arg(Pbf)-OH
D-Arg(NO2)-OH / N-NO2-D-Arg	Fmoc-HoArg(Pbf)-OH
HL-Arg(NO2)-OH	Fmoc-Arg(Tos)-OH
HL-Arg(Tos)-OH	Fmoc-D-Arg(Tos)-OH
L-Arg-NH2	Fmoc-D-Arg(Pbf)-OH
Boc-L-Arg-OH	Cbz-Arg-OH
Boc-D-Arg(Pbf)	Cbz-D-Arg-OH
Boc-Arg-Oet	Cbz-L-Arg(Pbf)-OH
Boc-L-Arg-Ome	Cbz-D-Arg(pbf).CHA
Boc-L-Arg(Tos)-OH	Cbz-D-Arg-Gly-OH
Boc-L-Arg(NO2)-OH	L-Arg(Pbf)-Asp
Fmoc-L-HomoArg-OH	L-Homoarg.hcl

Superiority

1. R&D sevhisi iripo
2. ISO yakasimbiswa mugadziri, vimbiso yehutano
3.Nzira yakazara yebasa rekutevera panguva yekugadzirwa
4.Kudhura kwakanyanya
5.Quality certification magwaro anopiwa pane chikumbiro chemutengi
6.Great after-sales service, kuchengetedza ukama hwepedyo nemutengi
7.Full resource kubatsira kuderedza mari yekutumira
8.Free sampuli yakapihwa kuti utarise kunaka kusati kwabhadharwa
9.Payment term yakataurirana
10.Assit vatengi vanobata nenyaya muChina