15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

White crystalline powder;Isingasviki mumvura uye petroleum ether, soluble mu ethyl acetate uye methanol;mp is 115-116 ℃;Kutenderera chaiko [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
Inoshandiswa polypeptide synthesis, seamino acid inodzivirira monomer.
O-benzyl-l-threonine yakamiswa mu dioxane solution uye acylated ne tert-butylcarbonyl aside kuti iwane crude product, iyo yakatorwa ne ethyl acetate pa pH ye9-10 ndokuzodzokororwa.
Chinhu chinoshanda che thymic oietin Ⅱ ye thymus secretions.Thymoietin II inhengo imwe chete yepolypeptide yakaparadzaniswa nehomoni yethymus.Inoumbwa ne 49 amino acids, uye peptide cheni fragment inoumbwa ne5 amino acids ine mabasa ese akafanana emuviri se thymoietin II.Naizvozvo, ichi pentapeptide chidimbu chinonzi thymus pentapeptide.White kuomesa-yakaomeswa yakasununguka yakawanda kana hupfu.
Rimwe remabasa e thymus pentapeptide ndere kuunza T cell kusiyaniswa.Inogona kuita sarudzo yekukurudzira shanduko yeThy-1-prothorax maseru kuita Thy-1+ T masero.Kusiyanisa kweT cell kunopindirana nekuwedzera intracellular cAMP mazinga.Rimwe basa rinokosha re thymus pentapeptides ndere kusunga kune chaiwo mareceptor emasero eropa eropa T akura, kuwedzera intracellular cAMP level, uye nekudaro kuunza nhevedzano ye intracellular reactions, inovawo hwaro hweiyo immunomodulatory basa.Mune yakajairika mamiriro emuviri, thymus pentapeptide yakaratidza immune stimulating mhedzisiro, iyo inogona zvakanyanya kuwedzera E rosette kuumbwa mwero uye kutendeuka chiyero che splenic lymphocytes, kuwedzera matanho akasiyana ekutanga kana echipiri immune mhinduro, uye kuwedzera huwandu hweIgM mhando uye IgG kana IgA type antibody inogadzira maseru.Thymus pentapeptide inogona zvakare kusimudzira phagocytosis basa re macrophage, kuwedzera enzyme uye phagocytosis basa re polymorphonuclear neutrophils, kuwedzera kutenderera kweanopokana nemukati, uye kuwedzera immune basa remasero matsvuku eropa.Thymus pentapeptide inogona kumisa CD4 uye CD8 masero akanaka, kuitira kuti chaiwo maTc masero anogona kuchengetedza hupenyu hwakareba, asiwo anogona kumisa masero eT uye kukurudzira kushanda kweT masero.Iyo inorwisa hutachiona uye yekurapa mhedzisiro yethymus pentapeptide ine hukama nekusimudzira kwayo kweTC cell chiitiko.Nhamba yakakodzera ye thymus pentapeptide inogona kuwedzera zvakanyanya kugadzirwa kwe interferon mukudzivirira hutachiona.Kukurudzira nekusimudzira T cell kusiyanisa uye kukura;CD4/CD8 yaiwanzova yakajairika nekugadzirisa chikamu cheT lymphocyte subsets;Kuvandudza phagocytosis basa re macrophages;Kuvandudza masero matsvuku eropa;Wedzera basa remasero anouraya echisikigo;Wedzera chiyero che interleukin-2 kugadzirwa uye receptor kutaura;Kuvandudza kugadzirwa kwe γ interferon mu peripheral blood mononuclear cells;Wedzera chiitiko cheSOD mu serum.
Inogona kushandiswa mune yakashata bundu varwere vane immune basa kusagadzikana mushure meradiotherapy uye chemotherapy.Kurapa kwehepatitis B;Kuvhiya kukuru uye zvirwere zvakanyanya;Autoimmune zvirwere zvakadai rheumatoid arthritis, lupus erythematosus;Type II chirwere cheshuga mellitus, menopause syndrome;Munhu ane simba rekudzivirira muviri.