China 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Mugadziri uye Factory |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Tsanangudzo Pfupi:

Chitarisiko	Machena kusvika kuOff-White makristasi kana crystalline poda.
MF	C16H22N2O6
MW	338.36
Kuchena	98+

Tumira email kwatiri

Product Detail

Mamiriro ekufambisa & inokurudzirwa nzira yekutumira:
nemhepo, negungwa kana nekutaura

Mamiriro ekuchengetedza:
Yakavharwa pakaoma, Room Temperature

Minimum Order Qty:
Kukurukurirana

Certification:
COA, HPLC, GC, HNMR, Assay, Mvura Yemukati(KF), TLC iripo

Mashoko anoreva zvakafanana

(S)-ethyl 2-(tert-butoxycarbonylaMino)-3-(4-nitrophenyl)propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N- [(1,1-dimethylethoxy) carbonyl] -4-nitro-, ethyl ester

Inner Packing

Vanowanzo shandiswa kutakura hupfu.Uye vanogona kudzivirira kupenya kwezuva nemvura kuti zvisashata.

kurongedza kwekunze

Iyo hard carton inogona kuchengetedza zvigadzirwa zvako kubva pakuputsika uye kunyorova.

Applications

Nidanib, ikemikari.Zita remakemikari 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino]ne heartland yemethyl] - 2 - oxygen -, methyl ester, (z) - Clinically, chigadzirwa ichi chinoshandiswa kurapa idiopathic pulmonary fibrosis (IPF).
Nidanib akadzidza 1,529 varwere vane idiopathic pulmonary fibrosis (IPF) mumakiriniki akawanda miedzo.Iyo data yekuchengetedza yakapihwa yakavakirwa pakuenzanisa kwevarwere ve1061 vakapihwa nidanib 150 mg kaviri zuva nezuva uye placebo mune maviri 52-vhiki chikamu 3, randomized, double-blind, placebo-controlled controlled studies (INPULSIS-1 uye INPULSIS-2).Zviitiko zvinowanzoitika zvakashata zvinosanganiswa nekushandiswa kwenidanib zvaisanganisira manyoka, kushungurudza uye kurutsa, kurwadziwa kwepamuviri, kurasikirwa kwechido, kuora muviri, uye kukwidziridzwa kwechiropa enzymes.Ndokumbira utarise kune [Kungwarira] kune manejimendi einoenderana yakashata maitiro.Iyo Systematic Organ Classification (SOC) yeMedDRA inopa pfupiso yeakaipa maitiro uye frequency kurongedza.
Nidanib isubstrate yeP-gp (ona Pharmacokinetics).Muchidzidzo chakananga chekubatana kwezvinodhaka, kusanganiswa kwekutonga kwe ketoconazole, P-gp inhibitor ine simba, yakawedzera kuratidzwa kune nidanib kusvika ku1.61 nguva nenzvimbo iri pasi pe curve (AUC) uye 1.83 nguva nepamusoro-soro (Cmax).
Muchidzidzo chekudyidzana kwezvinodhaka neine simba P-gp inducer rifampicin, kuratidzwa nidanib kwakadzikira kusvika pa50.3%, sekuyerwa nenharaunda iri pasi pe curve (AUC), kana yasanganiswa ne rifampicin zvichienzaniswa neNidanib chete.Ne peak concentration (Cmax), yakadzikira kusvika 60.3%.
Kana ichishandiswa pamwe chete nechigadzirwa ichi, P-gp inhibitors ine simba (eg, ketoconazole kana erythromycin) inogona kuwedzera kuonekwa kune nidanib.Muzviitiko izvi, kushivirira kwemurwere kune nidanib kunofanira kunyatsoongororwa.Kutonga kwemaitiro akashata kungada kuregedzwa, kuderedzwa kwedosing, kana kurega kurapwa nechigadzirwa ichi (ona [Kushandiswa uye chipimo]).
P-gp potent inducers (semuenzaniso, rifampicin, carbamazepine, phenytoin uye St. John's wort) inogona kuderedza kuratidzwa kwe nidanib.Alternative masanganiswa asina kana kushoma P-gp induction inofanirwa kutariswa.

zvinoenderana zvigadzirwa

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe (4-NO2)-OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe (4-NO2).H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Superiority

1. R&D sevhisi iripo
2. ISO yakasimbiswa mugadziri, vimbiso yehutano
3.Nzira yakazara yebasa rekutevera panguva yekugadzirwa
4.Kudhura kwakanyanya
5.Quality certification magwaro anopiwa pane chikumbiro chemutengi
6.Great after-sales service, kuchengetedza ukama hwepedyo nemutengi
7.Full resource kubatsira kuderedza mari yekutumira
8.Free sampuli yakapihwa kuti utarise kunaka kusati kwabhadharwa
9.Payment term yakataurirana
10.Assit vatengi vanobata nenyaya muChina