22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide inozivikanwawo seHaizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, uye ipratropium bromide.Iyo chena crystalline poda ine inovava.Kunyungudika 232 ℃-233 ℃.Soluble mumvura, zvishoma soluble mu ethanol, isinganyunguriki mune mamwe organic solvents.Zita remakemikari: Brominated α- (hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Iyo anticholinergic drug, ine yakasimba kuzorora mhedzisiro pabronchial yakatsetseka tsandanyama uye antiasthmatic mhedzisiro pane isingaperi obstructive pulmonary chirwere.Mhedzisiro yaro iri pachena, inokurumidza kuita uye kwenguva refu.Ipratropium bromide inodzorawo kuvharirwa kwemachuru uye inonatsiridza kufamba kweciliary, nokudaro ichideredza kuvharika kwesputum kuvandudza mhepo.Zvichakadaro, kuderedzwa kwesputum kunoderedzawo bronchospasm inokonzerwa nekutsamwa kwebronchi.Nekudzivirira uye kurapwa kwebronchial asthma uye asthmatic isingaperi bronchitis, kunyanya kune varwere vasingakwanisi kushivirira kushandiswa kwe β-agonist tsandanyama kudengenyeka, tachycardia.Ichi chigadzirwa chinogona kushandiswa pamwe chete ne beta-agonists kuwedzera kushanda kweumwe neumwe, senge musanganiswa nefinoterol kugadzira aerosol (BERODU - AL) yeasthma, chronic bronchitis uye emphysema.Zvichienzaniswa ne-β-adrenergic receptor stimulants (eg, isopropyl epinephrine), chigadzirwa ichi chine zvishoma zvinokonzerwa nemwoyo, uye zvichienzaniswa ne-β2-receptor stimulants (semuenzaniso, Suquanling), chigadzirwa ichi chine simba rakasimba rekugadzirisa pahuwandu hwephlegm.
Spray inhalation.40 ~ 80μg kamwe, 2 ~ 4 kanomwe pazuva.Paunenge uchishandisa, tanga wabvisa kavha yevhavha yevhavha, isa ziso rekuvharisa ziso pamuromo, shandura bhodhoro pasi, isa goko rekuvharira mumuromo, tarisa pahuro, sveta gasi panguva imwe chete, dzvanya muromo. pavharuvhu, inhale mvura, bata kufema kwako kwechinguva.Dzokorora snap iri pamusoro kamwe kana zvichidikanwa.Aerosol: 0.025% mhinduro.Tablet: 10mg/ piritsi.
Muchetura wakanyanya anticholinergic unogona kurapwa necholinesterase inhibitors.
Maitiro akashata eipratropium bromide akafanana neatropine, iyo inogona kukonzera palpation, kutemwa nemusoro, dzungu, kutya, kusvotwa, kurutsa, marwadzo emudumbu, kudedera, kusaona zvakanaka, muromo wakaoma, kukosora, dysuria, kuwedzera kwezviratidzo zvekufema uye kuputika.
Ipratropium bromide muscarinic antagonist, bronchodilator, uye isopropyl munyu weAtropineN.
Ipratropiumbromide neFormoterol zvakabatanidzwa pamwe kudzivirira mapapu kubva mukuzvimba kusingaperi uye kuwedzera mapapu, kuderedza neutrophils nekudzivisa basa kuburikidza neMMP-9.Ipratropiumbromide (1nM) yakawedzera zvakanyanya calcium bromide, yakaderedzwa kupararira mberi uye yakawedzera annexin-V kusunga.Mushure mekurapa kweIpratropiumbromide, hemolysis yakawedzera zvishoma asi zvakanyanya.Ipratropiumbromide inokonzera kuzviuraya kwesero dzvuku reropa kufa kana eryptosis, zvakanyanya nekuda kwekukurudzira kwecalcium.
Ipratropium dry powder inhalation (DPI) yaiva bronchodilator inoshanda mukuzorora kwemabhiza pachiyero che 2400 mg / bhiza, ine zvishoma zvishoma pamhepo yepamusoro yemhepo panguva yekupora.Mumakonzo akabatwa necadmium, Ipratropium yakanyanyisa parenchymal inflammatory cell inflow uye yakaona maronda emapapu akazara.Ipratropium inodzivirira zvishoma mapapu kubva mukuzvimba nekudzikisa neutrophil infiltration.Muguinea yenguruve tracheal yakatsetseka tsandanyama, Ipratropium inopikisa inodzivisa prebound muscarinic inhibitory receptor yemapapu parasympathetic nerve.Ipratropium yakaratidzawo kuva anopikisa ane simba mushure mekuvhara kune muscarinic inhibitory receptors.Ipratropium inoderedza zvakanyanya shanduko mukudzivirira kwechipfuva uye inowedzera kusimba kutevedzera (Cdyn) mumhepo yekufema (inowedzera Pplmax) uye pulmonary resistance (RL) mumabhiza.